If the MCU does not have an internal D+ pullup and there is no dedicated GPIO to simulate a USB disconnect, the D+ GPIO is temporarily configured as an output and pushed down to simulate a disconnect/connect cycle to allow the host to recognize the device. However, this requires an external pullup on D+ signal to work
If `RCC_CFGR_USBPRE` is defined, the USB device FS clock of 48 MHz is derived from the PLL clock. In this case the PLL clock must be configured and must be either 48 MHz or 72 MHz. If the PLL clock is 72 MHz it is pre-divided by 1.5, the PLL clock of 48 MHz is used directly.
For a number of STM32 MCUs with the USB-FS device interface the signals USB_DP and USB_DM are not defined as GPIO alternative function but as additional function. Additional functions are directly selected/enabled through peripheral registers hand have not to be configured. In this case, the configuration defines GIO_AF_UNDEF as alternative function.