diff --git a/cpu/samd21/periph/i2c.c b/cpu/samd21/periph/i2c.c
index 037dbf81a4..8977b7190b 100644
--- a/cpu/samd21/periph/i2c.c
+++ b/cpu/samd21/periph/i2c.c
@@ -23,7 +23,6 @@
 #include "mutex.h"
 #include "periph_conf.h"
 #include "periph/i2c.h"
-#include "instance/instance_sercom3.h"
 
 #include "sched.h"
 #include "thread.h"