diff --git a/cpu/nrf52/Kconfig b/cpu/nrf52/Kconfig
index 13893255f9..21fa0544ba 100644
--- a/cpu/nrf52/Kconfig
+++ b/cpu/nrf52/Kconfig
@@ -14,6 +14,7 @@ config CPU_FAM_NRF52
     select HAS_BLE_NIMBLE_NETIF
     select HAS_CORTEXM_MPU
     select HAS_CPU_NRF52
+    select HAS_PERIPH_I2C_RECONFIGURE
 
 ## CPU Models
 config CPU_MODEL_NRF52805XXAA
diff --git a/cpu/nrf52/Makefile.features b/cpu/nrf52/Makefile.features
index a37f2a28de..3bcda9ceca 100644
--- a/cpu/nrf52/Makefile.features
+++ b/cpu/nrf52/Makefile.features
@@ -20,4 +20,6 @@ FEATURES_PROVIDED += ble_nimble_netif
 # all nrf52 have an MPU
 FEATURES_PROVIDED += cortexm_mpu
 
+FEATURES_PROVIDED += periph_i2c_reconfigure
+
 include $(RIOTCPU)/nrf5x_common/Makefile.features
diff --git a/cpu/nrf52/include/periph_cpu.h b/cpu/nrf52/include/periph_cpu.h
index 5d76239463..850c8b1888 100644
--- a/cpu/nrf52/include/periph_cpu.h
+++ b/cpu/nrf52/include/periph_cpu.h
@@ -137,6 +137,14 @@ typedef struct {
 #define PERIPH_I2C_NEED_WRITE_REG
 /** @} */
 
+/**
+ * @name    Define macros for sda and scl pin to be able to reinitialize them
+ * @{
+ */
+#define i2c_pin_sda(dev) i2c_config[dev].sda
+#define i2c_pin_scl(dev) i2c_config[dev].scl
+/** @} */
+
 /**
  * @name    The PWM unit on the nRF52 supports 4 channels per device
  */
diff --git a/cpu/nrf52/periph/i2c.c b/cpu/nrf52/periph/i2c.c
index cabdedd797..9888f8a68e 100644
--- a/cpu/nrf52/periph/i2c.c
+++ b/cpu/nrf52/periph/i2c.c
@@ -87,6 +87,14 @@ static int finish(i2c_t dev)
     return 0;
 }
 
+static void _init_pins(i2c_t dev)
+{
+    gpio_init(i2c_config[dev].scl, GPIO_IN_OD_PU);
+    gpio_init(i2c_config[dev].sda, GPIO_IN_OD_PU);
+    bus(dev)->PSEL.SCL = i2c_config[dev].scl;
+    bus(dev)->PSEL.SDA = i2c_config[dev].sda;
+}
+
 void i2c_init(i2c_t dev)
 {
     assert(dev < I2C_NUMOF);
@@ -99,22 +107,42 @@ void i2c_init(i2c_t dev)
     /* disable device during initialization, will be enabled when acquire is
      * called */
     bus(dev)->ENABLE = TWIM_ENABLE_ENABLE_Disabled;
+
     /* configure pins */
-    gpio_init(i2c_config[dev].scl, GPIO_IN_OD_PU);
-    gpio_init(i2c_config[dev].sda, GPIO_IN_OD_PU);
-    bus(dev)->PSEL.SCL = i2c_config[dev].scl;
-    bus(dev)->PSEL.SDA = i2c_config[dev].sda;
+    _init_pins(dev);
+
     /* configure dev clock speed */
     bus(dev)->FREQUENCY = i2c_config[dev].speed;
 
     spi_twi_irq_register_i2c(bus(dev), i2c_isr_handler, (void *)dev);
 
-    /* re-enable the device. We expect that the device was being acquired before
+    /* We expect that the device was being acquired before
      * the i2c_init_master() function is called, so it should be enabled when
      * exiting this function. */
     bus(dev)->ENABLE = TWIM_ENABLE_ENABLE_Enabled;
 }
 
+#ifdef MODULE_PERIPH_I2C_RECONFIGURE
+void i2c_init_pins(i2c_t dev)
+{
+    assert(dev < I2C_NUMOF);
+
+    _init_pins(dev);
+
+    bus(dev)->ENABLE = TWIM_ENABLE_ENABLE_Enabled;
+
+    mutex_unlock(&locks[dev]);
+}
+
+void i2c_deinit_pins(i2c_t dev)
+{
+    assert(dev < I2C_NUMOF);
+
+    mutex_lock(&locks[dev]);
+    bus(dev)->ENABLE = TWIM_ENABLE_ENABLE_Disabled;
+}
+#endif /* MODULE_PERIPH_I2C_RECONFIGURE */
+
 int i2c_acquire(i2c_t dev)
 {
     assert(dev < I2C_NUMOF);