diff --git a/cpu/cc26xx_cc13xx/periph/uart.c b/cpu/cc26xx_cc13xx/periph/uart.c
index 3f7db1c410..f1c01256fd 100644
--- a/cpu/cc26xx_cc13xx/periph/uart.c
+++ b/cpu/cc26xx_cc13xx/periph/uart.c
@@ -64,7 +64,7 @@ int uart_init(uart_t uart, uint32_t baudrate, uart_rx_cb_t rx_cb, void *arg)
     int cts_pin = uart_config[uart].cts_pin;
 #endif
 
-    if (uart == 0) {
+    if ((UART_NUMOF == 1) || (uart == 0)) {
         /* UART0 requires serial domain to be enabled */
         if (!power_is_domain_enabled(POWER_DOMAIN_SERIAL)) {
             power_enable_domain(POWER_DOMAIN_SERIAL);