diff --git a/boards/samr21-xpro/Makefile.include b/boards/samr21-xpro/Makefile.include
index 0c4862de71..9e5bbf58a1 100644
--- a/boards/samr21-xpro/Makefile.include
+++ b/boards/samr21-xpro/Makefile.include
@@ -1 +1,6 @@
+# If port selection via ttys.py is enabled by `MOST_RECENT_PORT=1`, filter
+# USB serials to only select the UART bridge of the embedded EDBG CMSIS-DAP
+# debugger.
+TTY_BOARD_FILTER := --model 'EDBG CMSIS-DAP'
+
 include $(RIOTMAKE)/boards/sam0.inc.mk