diff --git a/cpu/rpx0xx/clock.c b/cpu/rpx0xx/clock.c
index 424632b263..3af4252951 100644
--- a/cpu/rpx0xx/clock.c
+++ b/cpu/rpx0xx/clock.c
@@ -177,3 +177,17 @@ void clock_gpout3_configure(uint32_t f_in, uint32_t f_out, CLOCKS_CLK_GPOUT3_CTR
     io_reg_atomic_set(&PADS_BANK0->GPIO25, 1U << PADS_BANK0_GPIO25_IE_Pos);
     gpio_set_function_select(25, FUNCTION_SELECT_CLOCK);
 }
+
+void clock_adc_configure(CLOCKS_CLK_ADC_CTRL_AUXSRC_Enum aux)
+{
+    /* Stop the clock generator */
+    io_reg_atomic_clear(&CLOCKS->CLK_ADC_CTRL,
+                        (1u << CLOCKS_CLK_ADC_CTRL_ENABLE_Pos));
+    /* Selects the new auxiliary clock source */
+    io_reg_write_dont_corrupt(&CLOCKS->CLK_ADC_CTRL,
+                              aux << CLOCKS_CLK_ADC_CTRL_AUXSRC_Pos,
+                              CLOCKS_CLK_ADC_CTRL_AUXSRC_Msk);
+    /* Restart the clock generator */
+    io_reg_atomic_set(&CLOCKS->CLK_ADC_CTRL,
+                      (1u << CLOCKS_CLK_ADC_CTRL_ENABLE_Pos));
+}
diff --git a/cpu/rpx0xx/cpu.c b/cpu/rpx0xx/cpu.c
index 61fd73f773..6fa88532d5 100644
--- a/cpu/rpx0xx/cpu.c
+++ b/cpu/rpx0xx/cpu.c
@@ -41,6 +41,7 @@ static void _cpu_reset(void)
         |   RESETS_RESET_pll_usb_Msk
         |   RESETS_RESET_pll_sys_Msk
         |   RESETS_RESET_pads_qspi_Msk
+        |   RESETS_RESET_pads_bank0_Msk
         |   RESETS_RESET_io_qspi_Msk);
     periph_reset(rst);
     /* Assert that reset has completed except for those components which
@@ -78,6 +79,13 @@ static void _cpu_reset(void)
         clock_gpout0_configure(CLOCK_XOSC, CLOCK_XOSC,
                                CLOCKS_CLK_GPOUT0_CTRL_AUXSRC_clk_ref);
     }
+
+    /* Configure USB PLL to deliver 48MHz needed by ADC */
+    if (IS_USED(MODULE_PERIPH_ADC)) {
+        pll_start_usb(PLL_USB_REF_DIV, PLL_USB_VCO_FEEDBACK_SCALE,
+                      PLL_USB_POSTDIV1, PLL_USB_POSTDIV2);
+        clock_adc_configure(CLOCKS_CLK_ADC_CTRL_AUXSRC_clksrc_pll_usb);
+    }
 }
 
 void cpu_init(void)
diff --git a/cpu/rpx0xx/include/periph_cpu.h b/cpu/rpx0xx/include/periph_cpu.h
index a0d7e0584d..0d137f9add 100644
--- a/cpu/rpx0xx/include/periph_cpu.h
+++ b/cpu/rpx0xx/include/periph_cpu.h
@@ -613,6 +613,13 @@ void clock_gpout2_configure(uint32_t f_in, uint32_t f_out, CLOCKS_CLK_GPOUT2_CTR
  */
 void clock_gpout3_configure(uint32_t f_in, uint32_t f_out, CLOCKS_CLK_GPOUT3_CTRL_AUXSRC_Enum aux);
 
+/**
+ * @brief   Configure the ADC clock to run from a dedicated auxiliary
+ *          clock source
+ *
+ * @param   aux     Auxiliary clock source
+ */
+void clock_adc_configure(CLOCKS_CLK_ADC_CTRL_AUXSRC_Enum aux);
 /** @} */
 
 /**