diff --git a/cpu/msp430/Makefile.features b/cpu/msp430/Makefile.features
index d471c01e38..7107cccde9 100644
--- a/cpu/msp430/Makefile.features
+++ b/cpu/msp430/Makefile.features
@@ -24,4 +24,5 @@ FEATURES_PROVIDED += periph_pm
 FEATURES_PROVIDED += periph_timer_query_freqs
 
 FEATURES_PROVIDED += periph_gpio_ll
+FEATURES_PROVIDED += periph_gpio_ll_irq
 FEATURES_PROVIDED += periph_gpio_ll_switch_dir
diff --git a/cpu/msp430/periph/gpio_ll_irq.c b/cpu/msp430/periph/gpio_ll_irq.c
new file mode 100644
index 0000000000..5ebaa1f09d
--- /dev/null
+++ b/cpu/msp430/periph/gpio_ll_irq.c
@@ -0,0 +1,145 @@
+/*
+ * Copyright (C) 2024 Marian Buschsieweke
+ *
+ * This file is subject to the terms and conditions of the GNU Lesser General
+ * Public License v2.1. See the file LICENSE in the top level directory for more
+ * details.
+ */
+
+/**
+ * @ingroup     cpu_msp430
+ * @ingroup     drivers_periph_gpio_ll_irq
+ * @{
+ *
+ * @file
+ * @brief       IRQ implementation of the GPIO Low-Level API for MSP430
+ *
+ * @author      Marian Buschsieweke <marian.buschsieweke@posteo.net>
+ *
+ * @}
+ */
+
+#include <errno.h>
+#include <stdbool.h>
+
+#include "compiler_hints.h"
+#include "container.h"
+#include "periph/gpio_ll.h"
+#include "periph/gpio_ll_irq.h"
+
+#define ENABLE_DEBUG 0
+#include "debug.h"
+
+#define ISR_PORTS_NUMOF     2U
+#define PINS_PER_PORT       8U
+#define ISR_NUMOF           (ISR_PORTS_NUMOF * PINS_PER_PORT)
+
+struct isr_ctx {
+    gpio_ll_cb_t cb;
+    void *arg;
+};
+
+static struct isr_ctx _isr_ctx[ISR_NUMOF];
+
+static unsigned _idx(uword_t port_num, uint8_t pin)
+{
+    if (port_num == 2) {
+        return pin + 8;
+    }
+
+    return pin;
+}
+
+int gpio_ll_irq(gpio_port_t _port, uint8_t pin, gpio_irq_trig_t trig,
+                gpio_ll_cb_t cb, void *arg)
+{
+    uword_t port_num = gpio_port_num(_port);
+    if (unlikely((port_num > 2) || (port_num == 0))) {
+        DEBUG_PUTS("[gpio_ll_irq] GPIO port without IRQ support used");
+        return -ENOTSUP;
+    }
+
+    switch (trig) {
+    case GPIO_TRIGGER_EDGE_RISING:
+    case GPIO_TRIGGER_EDGE_FALLING:
+        break;
+    default:
+        DEBUG_PUTS("[gpio_ll_irq] unsupported trigger used");
+        return -ENOTSUP;
+    }
+
+    msp430_port_p1_p2_t *port = container_of((msp430_port_t *)_port, msp430_port_p1_p2_t, base);
+
+    unsigned idx = _idx(port_num, pin);
+    uword_t mask = 1U << pin;
+
+    /* Disable IRQs to avoid race when updating CTX. Relying on compiler to
+     * use BIC.B instruction to implement this, which is inherently atomic. */
+    port->IE &= ~mask;
+    _isr_ctx[idx].cb = cb;
+    _isr_ctx[idx].arg = arg;
+
+    /* Configuring interrupt edge select. Relying on atomic BIS.B and BIC.B
+     * instructions used by the compiler */
+    port->IES &= ~mask;
+    if (trig == GPIO_TRIGGER_EDGE_FALLING) {
+        port->IES |= mask;
+    }
+
+    /* Clear pending IRQs, relying on atomic BIC.B instruction used by the
+     * compiler. */
+    port->IFG &= ~mask;
+
+    /* Finally, enabling the IRQ, relying on atomic BIS.B instruction used by
+     * the compiler */
+    port->IE |= mask;
+
+    return 0;
+}
+
+/* It appears that disabling the interrupt in IE does not only mask IRQs,
+ * but disables the IRQ edge detector hardware completely. Hence, IRQs
+ * that came in while masked will not trigger after unmasking, as the
+ * API would expect. For this reason, we don't provide gpio_ll_irq_unmask() but
+ * only gpio_ll_irq_unmask_and_clear().
+ */
+void gpio_ll_irq_mask(gpio_port_t _port, uint8_t pin)
+{
+    msp430_port_p1_p2_t *port = container_of((msp430_port_t *)_port, msp430_port_p1_p2_t, base);
+    port->IE &= ~(1U << pin);
+}
+
+void gpio_ll_irq_unmask_and_clear(gpio_port_t _port, uint8_t pin)
+{
+    msp430_port_p1_p2_t *port = container_of((msp430_port_t *)_port, msp430_port_p1_p2_t, base);
+    uword_t mask = 1U << pin;
+    /* We clear IFG anyway despite bits in IFG not getting set without IE, a
+     * call may rely on this function clearing IRQs while already unmasked. */
+    port->IFG &= ~mask;
+    port->IE |= mask;
+}
+
+static void _isr_handler(msp430_port_p1_p2_t *port, int ctx)
+{
+    for (unsigned i = 0; i < PINS_PER_PORT; i++) {
+        unsigned mask = 1U << i;
+        if ((port->IE & mask) && (port->IFG & mask)) {
+            port->IFG &= ~mask;
+            _isr_ctx[i + ctx].cb(_isr_ctx[i + ctx].arg);
+        }
+    }
+}
+
+ISR(PORT1_VECTOR, isr_port1)
+{
+    __enter_isr();
+    _isr_handler(&PORT_1, 0);
+    __exit_isr();
+}
+
+ISR(PORT2_VECTOR, isr_port2)
+{
+    __enter_isr();
+    _isr_handler(&PORT_2, 8);
+    __exit_isr();
+}