diff --git a/cpu/stm32/Makefile.dep b/cpu/stm32/Makefile.dep
index 438c609426..4bc8896a49 100644
--- a/cpu/stm32/Makefile.dep
+++ b/cpu/stm32/Makefile.dep
@@ -4,12 +4,19 @@
 USEMODULE += periph stm32_clk stm32_vectors
 
 ifneq (,$(filter periph_usbdev,$(FEATURES_USED)))
-  # All STM32 families except for STM32F1, STM32F3 and STM32WG use synopsys_dwc2
-  ifeq (,$(filter f1 f3 wb,$(CPU_FAM)))
+  ifneq (,$(filter f2 f4 f7 h7 u5,$(CPU_FAM)))
+    # Whole STM32 families F2, F4, F7, H7 and U5 use the Synopsys DWC2 USB OTG core
     USEMODULE += usbdev_synopsys_dwc2
-  endif
-  # In STM32F1 family STM32F105xx and STM32F107xx also use synopsys_dwc2
-  ifneq (,$(filter stm32f105% stm32f107%,$(CPU_MODEL)))
+  else ifneq (,$(filter stm32f105% stm32f107%,$(CPU_MODEL)))
+    # STM32F105xx and STM32F107xx also use the Synopsys DWC2 USB OTG core
+    USEMODULE += usbdev_synopsys_dwc2
+  else ifneq (,$(filter stm32l47% stm32l48% stm32l49%,$(CPU_MODEL)))
+    # STM32L475xx, STM32L476xx, STM32L485xx, STM32L486xx and STM32L496xx
+    # also use the Synopsys DWC2 USB OTG core
+    USEMODULE += usbdev_synopsys_dwc2
+  else ifneq (,$(filter stm32l4a% stm32l4p% stm32l4q% stm32l4r% stm32l4s%,$(CPU_MODEL)))
+    # STM32L4Axxx, STM32L4Pxxx, STM32L4Qxxx, STM32L4Rxxx and STM32L4Sxxx
+    # also use the Synopsys DWC2 USB OTG core
     USEMODULE += usbdev_synopsys_dwc2
   endif
   USEMODULE += ztimer
diff --git a/cpu/stm32/periph/Kconfig b/cpu/stm32/periph/Kconfig
index 9c81d3d51a..a15f74f45d 100644
--- a/cpu/stm32/periph/Kconfig
+++ b/cpu/stm32/periph/Kconfig
@@ -10,21 +10,30 @@ config MODULE_PERIPH
     default y
     select MODULE_ZTIMER if MODULE_PERIPH_USBDEV
     select MODULE_ZTIMER_MSEC if MODULE_PERIPH_USBDEV
-    # All STM32 families except for STM32F1, STM32F3 and STM32WG use
-    # MODULE_USBDEV_SYNOPSYS_DWC2
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && !HAS_CPU_STM32WB && !HAS_CPU_STM32F3 && !HAS_CPU_STM32F1
-    # In STM32F1 family STM32F105xx also uses MODULE_USBDEV_SYNOPSYS_DWC2.
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F105R8
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F105RB
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F105RC
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F105V8
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F105VB
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F105VC
-    # In STM32F1 family STM32F107xx also uses MODULE_USBDEV_SYNOPSYS_DWC2.
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F107RB
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F107RC
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F107VB
-    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_MODEL_STM32F107VC
+    # Whole STM32 families F2, F4, F7, H7 and U5 use the Synopsys DWC2 USB OTG core
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && HAS_CPU_STM32F2
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && HAS_CPU_STM32F4
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && HAS_CPU_STM32F7
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && HAS_CPU_STM32H7
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && HAS_CPU_STM32U5
+    # STM32F105xx and STM32F107xx lines also use the Synopsys DWC2 USB OTG core
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32F105XC
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32F107XC
+    # Several lines of STM32L4 family also use the Synopsys DWC2 USB OTG core
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L475XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L476XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L485XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L486XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L496XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4A6XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4P5XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4Q5XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4R5XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4R7XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4R9XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4S5XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4S7XX
+    select MODULE_USBDEV_SYNOPSYS_DWC2 if MODULE_PERIPH_USBDEV && CPU_LINE_STM32L4S9XX
     help
         stm32 common peripheral code.
 
diff --git a/pkg/tinyusb/Kconfig b/pkg/tinyusb/Kconfig
index c1224f5b59..490dd1bc1f 100644
--- a/pkg/tinyusb/Kconfig
+++ b/pkg/tinyusb/Kconfig
@@ -25,22 +25,61 @@ menuconfig PACKAGE_TINYUSB
     select MODULE_TINYUSB_CONTRIB
     select MODULE_TINYUSB_HW
     select MODULE_TINYUSB_PORTABLE_ESPRESSIF if CPU_FAM_ESP32S2 || CPU_FAM_ESP32S3
-    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_STM32 && CPU_FAM_F2
-    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_STM32 && CPU_FAM_F4
-    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_STM32 && CPU_FAM_F7
-    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_STM32 && CPU_FAM_H7
-    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_STM32 && CPU_FAM_L4
-    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_STM32 && CPU_FAM_F0
-    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_STM32 && CPU_FAM_F1
-    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_STM32 && CPU_FAM_G4
-    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_STM32 && CPU_FAM_L0
-    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_STM32 && CPU_FAM_WB
+    # Whole STM32 families F2, F4, F7 and U5 use the Synopsys DWC2 USB OTG core
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if HAS_CPU_STM32F2
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if HAS_CPU_STM32F4
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if HAS_CPU_STM32F7
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if HAS_CPU_STM32U5
+    # STM32F105xx and STM32F107xx lines also use the Synopsys DWC2 USB OTG core
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32F105XC
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32F107XC
+    # Several lines of STM32L4 family also use the Synopsys DWC2 USB OTG core
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L475XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L476XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L485XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L486XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L496XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4A6XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4P5XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4Q5XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4R5XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4R7XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4R9XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4S5XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4S7XX
+    select MODULE_TINYUSB_PORTABLE_SYNOPSYS_DWC2 if CPU_LINE_STM32L4S9XX
+    # Whole STM32 families F0, F3, G0, G4, L0, L1, L5 and WB use the Synopsys DWC2 USB OTG core
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32F0
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32F3
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32G0
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32G4
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32L0
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32L1
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32L5
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if HAS_CPU_STM32WB
+    # STM32F102xx and STM32F103xx lines also use USB FS Device core
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32F102X6
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32F102XB
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32F103X6
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32F103XB
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32F103XE
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32F103XG
+    # Following STM32L4 lines also use USB FS Device core
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L412XX
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L422XX
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L432XX
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L433XX
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L442XX
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L443XX
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L452XX
+    select MODULE_TINYUSB_PORTABLE_STM32_FSDEV if CPU_LINE_STM32L462XX
+    #
     select MODULE_TINYUSB_PORTABLE_MICROCHIP if CPU_FAM_SAMD21 || CPU_FAM_SAMR21 \
            || CPU_COMMON_SAMD5X || CPU_FAM_SAML21 || CPU_FAM_SAMR34 \
            || CPU_FAM_SAMR30
     select MODULE_TINYUSB_PORTABLE_NRF5X if CPU_FAM_NRF52
-    select PACKAGE_NRFX if CPU_FAM_NRF52
     select MODULE_ZTIMER_MSEC
+    select PACKAGE_NRFX if CPU_FAM_NRF52
     help
         tinyUSB is an open-source cross-platform USB Host/Device stack for
         embedded systems.
diff --git a/pkg/tinyusb/Makefile.dep b/pkg/tinyusb/Makefile.dep
index 80c81e5aa9..35fff35e1b 100644
--- a/pkg/tinyusb/Makefile.dep
+++ b/pkg/tinyusb/Makefile.dep
@@ -60,14 +60,22 @@ else ifeq (nrf52,$(CPU))
 else ifneq (,$(filter saml21 samd5x samd21,$(CPU)))
   USEMODULE += tinyusb_portable_microchip
 else ifeq (stm32,$(CPU))
-  ifneq (,$(filter f2 f4 f7 h7 l4,$(CPU_FAM)))
-    # STM32 families F2, F4, F7, H7 and L4 use the Synopsys DWC2 USB OTG IP core
+  ifneq (,$(filter f2 f4 f7 h7 u5,$(CPU_FAM)))
+    # Whole STM32 families F2, F4, F7, H7 and U5 use the Synopsys DWC2 USB OTG core
     USEMODULE += tinyusb_portable_synopsys_dwc2
   else ifneq (,$(filter stm32f105% stm32f107%,$(CPU_MODEL)))
-    # STM32F105xx and STM32F107xx also use the Synopsys DWC2 USB OTG IP core
+    # STM32F105xx and STM32F107xx also use the Synopsys DWC2 USB OTG core
+    USEMODULE += tinyusb_portable_synopsys_dwc2
+  else ifneq (,$(filter stm32l47% stm32l48% stm32l49%,$(CPU_MODEL)))
+    # STM32L475xx, STM32L476xx, STM32L485xx, STM32L486xx and STM32L496xx
+    # also use the Synopsys DWC2 USB OTG core
+    USEMODULE += tinyusb_portable_synopsys_dwc2
+  else ifneq (,$(filter stm32l4a% stm32l4p% stm32l4q% stm32l4r% stm32l4s%,$(CPU_MODEL)))
+    # STM32L4Axxx, STM32L4Pxxx, STM32L4Qxxx, STM32L4Rxxx and STM32L4Sxxx
+    # also use the Synopsys DWC2 USB OTG core
     USEMODULE += tinyusb_portable_synopsys_dwc2
   else
-    # All other STM32 MCUs use the USB Device FS IP core.
+    # all other STM32 with USB interface use USB FS Device core
     USEMODULE += tinyusb_portable_stm32_fsdev
   endif
 endif