diff --git a/tests/pkg_mbedtls/main.c b/tests/pkg_mbedtls/main.c
index 42905d502f..60e471506b 100644
--- a/tests/pkg_mbedtls/main.c
+++ b/tests/pkg_mbedtls/main.c
@@ -30,16 +30,35 @@ int main(void)
 {
     puts("mbedtls test\n");
 
-    /* Execute built-in tests */
+    /* Execute built-in tests SHA-2xx tests */
     mbedtls_sha256_self_test(1);
+
+    bool adc_noise_single_entropy = false;
+    /* NOTE, the following express needs adjustment when further entropy
+       sources added by RIOT */
+#if IS_USED(MODULE_MBEDTLS_ENTROPY_SOURCE_ADC) && !IS_USED(MODULE_MBEDTLS_ENTROPY_SOURCE_HWRNG)
+    /* If the adc noise entropy source is compiled and is the only source
+       utilized with the mbedtls entropy module, indicate it */
+    adc_noise_single_entropy = true;
+#endif
+    /* Used by the testrunner to ignore potential test failures it the case of
+       a single adc noise entropy source */
+    printf("adc_noise_single_entropy: %d\n", adc_noise_single_entropy);
+
+    /* Initializes available entropy sources */
+    entropy_mbedtls_riot_init();
+
+    /* Execute mbedtls built-in entropy tests*/
     mbedtls_entropy_self_test(1);
 
-    /* Execute convenience functions */
+    /* Execute convenience entropy functions */
     unsigned char out[4];
-    entropy_mbedtls_riot_init();
+    /* This function requires entropy_mbedtls_riot_init() beforehand */
     entropy_mbedtls_riot_retrieve(out, sizeof(out));
+    /* Clears the internal context again */
     entropy_mbedtls_riot_uninit();
 
+    /* This function does not require initialization */
     entropy_mbedtls_riot_get(out, sizeof(out));
 
     return 0;
diff --git a/tests/pkg_mbedtls/tests/01-run.py b/tests/pkg_mbedtls/tests/01-run.py
index 590e362e17..59bb4b2db5 100755
--- a/tests/pkg_mbedtls/tests/01-run.py
+++ b/tests/pkg_mbedtls/tests/01-run.py
@@ -17,7 +17,16 @@ def testfunc(child):
     child.expect_exact('SHA-256 test #1: passed')
     child.expect_exact('SHA-256 test #2: passed')
     child.expect_exact('SHA-256 test #3: passed')
-    child.expect_exact('ENTROPY test: passed')
+
+    # If the adc noise module is not a single entropy source, the ENTROPY test
+    # should succeed. Otherwise, if the adc noise module is the only entropy
+    # source, ignore a test failure which might be introduced by improver ADC
+    # configurations or properties. This still allows us to execute this test
+    # regardless of configuration specifics.
+    child.expect(r'adc_noise_single_entropy: (\d+)\r\n')
+    adc_noise_single_entropy = int(child.match.group(1))
+    if adc_noise_single_entropy == 0:
+        child.expect_exact('ENTROPY test: passed')
 
 
 if __name__ == "__main__":